Guanylate Cyclase

Related Products

Guanylate cyclase (guanylyl cyclase, GC), which catalyzes the formation of cGMP from GTP, exists in both the soluble and particulate fractions of cells. Guanylyl cyclases signal via the production of the second messenger cGMP.

The GC family consists of particulate GC (pGC) and a nitric oxide-activated soluble GC (sGC). Seven pGC isoforms have yet been found (pGC-A to pGC-G). pGCs are activated by binding of peptide ligands to their extracellular domains. sGC is a receptor for endogenous and exogenous nitric oxide and is activated several-fold upon its binding, constituting a core enzyme in the nitric oxide signal transduction pathway. cGMP generated by sGC is an important second messenger that regulates activity of several enzymes triggering such important physiologic reactions as vasodilation, smooth muscle relaxation and platelet aggregation.

Guanylate Cyclase Related Products (98)
Antibodies (2)

By Effects:	Activators (57)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P5077

Guanylin (mouse, rat)	Activator
Guanylin (mouse, rat), a petide, is composed of 15 amino acids. Guanylin (mouse, rat) is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) can be used for the research of diarrhea.

HY-184303

Antihypertensive agent 7	Activator
Antihypertensive agent 7 is a vasodilator. Antihypertensive agent 7 acts on vascular endothelial cells to activate the PI3K/AKT signaling axis, increase phosphorylated eNOS, release NO, activate the sGC/cGMP pathway in smooth muscle cells, and synergistically activate multiple K⁺ channels in vascular smooth muscle (K_ir/K_v/K_Ca/K_ATP, thereby inducing endothelium-dependent vasodilation. Antihypertensive agent 7 can be used in the research of hypertension.

HY-14779R

Riociguat (Standard)	Activator
Riociguat (Standard) is the analytical standard of Riociguat. This product is intended for research and analytical applications. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

HY-107546R

CFM 1571 hydrochloride (Standard)	Activator
CFM 1571 hydrochloride (Standard) is the analytical standard of CFM 1571 (hydrochloride) (HY-107546). This product is intended for research and analytical applications. CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC₅₀ and IC₅₀ of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 hydrochloride has the potential for the research of cardiovascular and other diseases.

HY-109039R

Praliciguat (Standard)	Activator
Praliciguat (Standard) is the analytical standard of Praliciguat (HY-109039). This product is intended for research and analytical applications. Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase (sGC) activator. Praliciguat can increases cGMP via the nitric oxide (NO)-sGC pathway. Praliciguat can inhibit the expression of proinflammatory cytoK_ines and inhibit apoptosis. Praliciguat can promote vasodilation. Praliciguat can be used for the researches of metabolic disease and cardiovascular disease, such as hypertension, diabetes and heart failure.

HY-109136R

Runcaciguat (Standard)	Activator
Runcaciguat (Standard) is the analytical standard of Runcaciguat (HY-109136). This product is intended for research and analytical applications. Runcaciguat (BAY 1101042) is a selective, orally active, allosteric activator of soluble guanylate cyclase (sGC) that specifically targets its oxidized and heme-free form. Runcaciguat binds to sGC in a histidine-dependent manner and restores cyclic guanosine monophosphate (cGMP) production under oxidative stress, independent of nitric oxide (NO) or heme. Runcaciguat exhibits renoprotective and cardioprotective activities, such as reduced proteinuria and improved renal function. Runcaciguat is primarily being studied in chronic K_idney disease (CK_d) associated with hypertension, diabetes, and metabolic disorders, as well as potential cardiovascular indications such as heart failure with preserved ejection fraction (HFpEF).

HY-14779S3

Riociguat-d₃	Activator
Riociguat-d₃ (BAY 632521-d₃) is deuterium labeled Riociguat. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

HY-109066R

Olinciguat (Standard)	Activator
Olinciguat (Standard) is the analytical standard of Olinciguat (HY-109066). This product is intended for research and analytical applications. Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.

HY-136781

A-350619	Activator
A-350619 is a novel sGC activator. A-350619 increases intracellular cGMP levels. A-350619 significantly induces penile erection.

HY-14927R

Lificiguat (Standard)	Activator
Lificiguat (Standard) is the analytical standard of Lificiguat. This product is intended for research and analytical applications. Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO.

HY-16774R

Vericiguat (Standard)	Activator
Vericiguat (Standard) is the analytical standard of Vericiguat. This product is intended for research and analytical applications. Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.

HY-107548

A-350619 hydrochloride	Activator
A-350619 hydrochloride is a soluble guanylate cyclase (sGC) activator. A-350619 hydrochloride can be used in the study of erectile dysfunction.

HY-16774S2

Vericiguat-d₆	Activator
Vericiguat-d₆ (BAY1021189-d₆) is deuterium labeled Vericiguat. Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.

HY-12376R

BAY 41-2272 (Standard)	Activator
BAY 41-2272 (Standard) is the analytical standard of BAY 41-2272. This product is intended for research and analytical applications. BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research.

HY-161681

Formycin triphosphate	Activator
Formycin triphosphate is a fluorescent analogue of ATP which on binding to enzyme active sites exhibits enhanced fluorescence. Formycin triphosphate is an ATP-competitive chicken liver pyruvate carboxylase inhibitor. Formycin triphosphate potentiates atrial natriuretic factor (ANF)-stimulated guanylate cyclase activity with an EC₅₀ at about 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC₅₀ at about 100 μM.

HY-14181AR

Cinaciguat hydrochloride (Standard)	Activator
Cinaciguat (hydrochloride) (Standard) is the analytical standard of Cinaciguat (hydrochloride). This product is intended for research and analytical applications. Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.

HY-14181R

Cinaciguat (Standard)	Activator
Cinaciguat (Standard) is the analytical standard of Cinaciguat. This product is intended for research and analytical applications. Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.

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Guanylate Cyclase

Guanylate Cyclase

Guanylate Cyclase Related Products (98)

Antibodies (2)

Guanylate Cyclase Related Products (98):